Richard B. Markham

A DNA vaccine targeting Mtb persisters reduces TB treatment duration in mice and elicits similar immune responses in macaques.

This study shows that an intranasal DNA vaccine targeting RelMtb with MIP3α induces T-cell infiltration in the lungs of mice and macaques, enhancing immune responses against Mtb.

This paper shows that combining IFN-alpha and 5-Aza-2-deoxycytidine with a MIP3alpha-Gp100-Trp2 DNA vaccine improves anti-tumor efficacy by enhancing T-cell recruitment and altering tumor microenvironment gene expression.