Stavros Azinas

The paper presents the cryo-EM structure of the MecA/ClpC/ClpP complex from Staphylococcus aureus, revealing how MecA facilitates substrate transfer and how ClpC/ClpP interactions are regulated by ATPase activity.

This study introduces AF_unmasked, a method that integrates experimental data with AlphaFold predictions to improve the accuracy of large protein complex structures.

This study shows that D2-HG induces cachexia in mice by disrupting NAD+ homeostasis and autophagy, revealing metabolic vulnerabilities in skeletal muscle.