Daniel N. Wilson

The paper identifies LudP, an arrest peptide that stalls translation by remodeling the ribosomal A-site, revealing its mechanism and evolutionary conservation.

This study determines the structures of 30S initiation complexes inhibited by kasugamycin, edeine, and GE81112, revealing distinct mechanisms of action within the E-site.

This study determines the structure of paenilamicin PamB2 bound to stalled ribosomes, revealing its mechanism as a context-specific translocation inhibitor of protein synthesis.

This study identifies YlmH as a novel RQC factor in B. subtilis, showing it can replace RqcP in polyalanine tail addition and is conserved in bacteria lacking RqcP.

This study identifies eEF3's role in promoting tRNA dissociation from the E site during translation elongation in fungi, revealing structural insights into the yeast translation cycle.

The paper identifies ResQ as a release factor-dependent ribosome rescue factor in Bacillus subtilis, showing it is essential for growth and functions by recruiting RF2 to stalled ribosomes.

This study identifies New1 as a translation termination factor in yeast by showing it binds the ribosome like eEF3 and affects ribosome queuing at stop codons.

The paper presents cryo-EM structures of hibernating 70S and 100S ribosomes from E. coli, revealing the roles of HPF and RMF in ribosome inactivation and dimerization.