Mary A. O’Connell

This study investigates the effects of Adar in Drosophila melanogaster, showing that overexpression of certain Adar isoforms leads to larval lethality and aberrant immune responses, with partial rescue through epigenetic modulation.

This paper develops a method to detect and quantify mRNA modifications like m6A, m6Am, and m1A in human RNA, revealing FTO's role in m6Am and ALKBH5's effect on inosine levels.

This study shows APP induces reactive astrogliosis in vitro and in vivo by remodeling intermediate filaments, enhancing cytokine production, and activating the IFN pathway.

The paper identifies PKR as a second dsRNA sensor aberrantly activated in Adar mutant mice and shows ADAR1 directly inhibits PKR through dsRNA-binding.