Lane K. Christenson

This study uses a VCD-induced menopause mouse model to show that ovarian loss disrupts hepatic mitochondrial function and lipid homeostasis, increasing susceptibility to diet-induced obesity and steatosis.

This study shows that sperm-oocyte interactions cause global and localized changes in cortical ER cluster structure during fertilization in mice.

The paper identifies ERβ-regulated genes in granulosa cells that are essential for ovarian follicle maturation beyond the antral stage, revealing both known and novel genes involved in this process.

The paper investigates inosine RNA modifications in oocytes from Cnot6l-/- and Btg4-/- mice, finding depletion of inosine modifications in Cnot6l-/- oocytes, suggesting a novel mRNA clearance mechanism.

This study shows that codon composition affects mRNA stability and protein abundance in human oocytes, with age-related changes in these associations impacting oocyte quality.

This study identifies that ADAR1-mediated A-to-I RNA editing in mouse oocytes preferentially targets the wobble position of codons, altering codon usage and potentially affecting mRNA stability and translation efficiency.