Sascha Schäuble

This study validates an alveolar-like macrophage model as a physiologically relevant in vitro system for studying early Aspergillus fumigatus infection dynamics.

This study shows that M-CSF enhances alveolar macrophage function to protect against invasive aspergillosis in immunocompromised mice.

This paper identifies transient GSK3β activation as a mechanism promoting disease tolerance to sepsis through hypometabolism, without affecting pathogen burden.

This study shows the murine lung microbiome is dynamic and transient, with bacteria rapidly cleared by the immune system and not establishing stable colonization.

This study identifies SmpR as a transcription factor that coordinates secondary metabolism and antibacterial defense in A. fumigatus in response to bacterial signals.

This study investigates how HCMV and its virokine CMVIL-10 modulate dendritic cell responses during co-infection with A. fumigatus, revealing that CMVIL-10 has a limited role in suppressing antifungal immunity.

This study shows that tRNA hypomodification in Aspergillus fumigatus leads to 5-fluorocytosine resistance through premature activation of a cross-pathway control system.

This study shows sodium chloride enhances CD8+ T-cell metabolic fitness and cytotoxicity, improving tumor cell killing in vitro and in vivo.

This study identifies galactosaminogalactan as the fungal ligand for CD56 on human NK cells, triggering antifungal responses and immune cell activation.

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