Chan-Wang J. Lio

The paper uses MNase digestion to stratify 5hmC in naive B cells, revealing that most 5hmC is nucleosome-associated, with minor subsets showing distinct chromatin accessibility patterns.

This study shows that loss of TET2 and TET3 in regulatory T cells leads to immune dysfunction and inflammation in mice.

This study shows TET enzymes enhance Aicda expression by depositing 5hmC at its superenhancer, promoting chromatin accessibility and CSR in B cells.