Omar De Bei

This study shows IsdH binds HbHp but does not support S. aureus growth under iron restriction when HbHp is the sole iron source, suggesting HbHp recognition has roles beyond iron acquisition.

This paper identifies C35 as a dual-acting compound that inhibits Staphylococcus aureus growth by blocking heme acquisition and modulates hemoglobin oxygen affinity.

The paper uses time-resolved X-ray solution scattering to study the molecular events of heme capture by IsdB from human hemoglobin.