Maciej Figiel

This study identifies early neurodevelopmental defects in juvenile-onset HD driven by choroid plexus overgrowth and altered paracrine signaling using organoid and mouse models.

The paper introduces the CSSG algorithm and JSEQ pipeline to discover high-resolution cell populations and their relationships in tissues using transcriptomic data.

The paper reviews transcriptomic data from PolyQ diseases to identify neurodevelopmental expression patterns and compare disease-related pathways across different conditions.

This study investigates the molecular mechanisms of SCA3/MJD using a knock-in mouse model, revealing axonal dysfunction and altered protein localization as key features of the disease.