Yingchun Han

This paper introduces AMPHORA, a pathogen-conditioned generator of antimicrobial peptides, showing that incorporating pathogen-specific features improves peptide design and potency.

The paper constructs a global virome atlas of cold seep ecosystems, revealing novel viral diversity and biotechnological potential.

This study reveals a distinct microbial-viral biome in sandy beaches, structured by tidal zonation, with high genomic novelty and metabolic shifts across cross-shore gradients.

The paper analyzes defense and anti-defense systems in microbes and viruses from cold seeps, revealing co-occurrence and coevolution of these systems across diverse microbial lineages.

The paper constructs a deep-sea small protein atlas, identifies noncanonical antimicrobial peptides, and demonstrates their antimicrobial efficacy and non-lytic mechanisms.

This study shows that seabed ecosystems rapidly collapse and form a methane biofilter after methane leakage from hydrates, with significant microbial and macrofaunal changes.

This study identifies and characterizes quorum sensing systems in deep-sea cold seep microbial communities, revealing their role in regulating biogeochemical processes.

The paper investigates reductive dehalogenation in deep-sea cold seeps, identifying diverse RDases and their ecological role in biogeochemical cycles.

This study analyzes the virulome and resistome of deep-sea cold seeps, finding minimal public health risks due to low abundance of high-risk genes and non-pathogenic functions.

This study identifies cold seeps as significant nitrogen-loss hotspots, revealing diverse microbial communities and active nitrogen-loss genes across multiple phyla.

This study tracks microbial succession, community assembly, and adaptation over five years at a deep-sea cold seep, revealing shifts in community structure and functional adaptations.

This study analyzes viral communities in marine biofilms on 8 materials to explore their roles in microbially influenced corrosion, finding viruses influence corrosion through interactions with corrosive microbes.

This study investigates secondary metabolites in cold seep microbiomes using metagenomic, metatranscriptomic, and metabolomic data, revealing diverse biosynthetic gene clusters and their potential ecological roles.