Paul H. Huang

This study combines collagen-targeted IL-12 with doxorubicin to improve anti-tumor effects in osteosarcoma by enhancing tumor accumulation and immune activation.

This paper identifies HDAC inhibition as a strategy to overcome resistance to EZH2 inhibitors in INI1-deficient epithelioid sarcoma by restoring H3K27 acetylation and enhancing therapeutic response.

SCAN-ACT identifies and prioritizes T cell therapy targets for solid tumors using single-cell transcriptomics and multi-omics data, validating targets through experimental methods.

This study shows circulating tumor cells shed shearosome extracellular vesicles in capillary bifurcations, which activate endothelial and immune cells and contribute to pre-metastatic niche formation.

This study identifies a DNA replication protein signature (SPM6) that improves risk stratification in soft tissue sarcomas when combined with the Sarculator nomogram.

This study compares proteomic profiles of adolescents and young adults with soft tissue tumours to older adults, identifying age-specific molecular features and potential therapeutic targets.