Sandro Pasquali

This study optimizes a subcutaneous xenograft model for EHE using patient-derived cells, showing that low cell densities produce reproducible tumors sensitive to mTOR inhibition.

This study identifies integrin signaling and cell-cycle deregulation as key drivers of SMARCB1-deficient epithelioid sarcoma and highlights therapeutic targets.

This paper identifies HDAC inhibition as a strategy to overcome resistance to EZH2 inhibitors in INI1-deficient epithelioid sarcoma by restoring H3K27 acetylation and enhancing therapeutic response.

This study identifies a Th2 immune program linked to desmoid tumor regression through active surveillance and multi-omics analysis.

This study identifies VCAN as a novel transcriptional target of ERK5 and shows its essential role in ERK5-driven tumorigenesis in soft tissue sarcoma.

This study identifies a DNA replication protein signature (SPM6) that improves risk stratification in soft tissue sarcomas when combined with the Sarculator nomogram.