Trevor R. Sweeney

The paper determines the structure of the picornaviral 2C:RNA holoenzyme complex, revealing RNA binding mechanisms and conservation across viral families.

This paper introduces scpImaging, a computational pipeline that uses microscopy data to detect multiplets and improve quality control in single-cell proteomics.

This study investigates how host differences affect ZIKV sfRNA accumulation in mammalian and insect cells, showing differential sensitivity to xrRNA2 structure absence.

The paper shows IFIT3 regulates IFIT1 stability and activity, preventing self mRNA targeting while maintaining antiviral function during the innate immune response.

The paper investigates the structural and mechanistic details of translation initiation on the enterovirus Type 1 IRES using cryo-electron microscopy, revealing key RNA-RNA interactions critical for viral replication.

This paper identifies ISG15/USP18/STAT2 as a molecular hub that regulates autocrine IFN-I signaling to control Dengue and Zika virus replication.