Styliani Markoulaki

The paper maps dopamine subtype projections in the basal ganglia to reveal spatially distinct domains and their correlation with striatal neuron subclasses and cortical inputs.

Prime-editing lineage trees for 16 mouse embryos (E7.5 to E10.0, >1.4 million cells) quantify fate restriction timing, progenitor numbers and lineage relationships, and are reproducible across replicate embryos.

This study genetically engineers mice to produce a protective antibody against Lyme disease, demonstrating heritable immunity that interrupts pathogen transmission.