Author

John Ferbas

Amgen (United States)ORCID 0000-0003-4087-4629Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Assay:metabolomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

David J. ShermaniD· 2 shared Ingrid C. RulifsoniD· 2 shared Jiansong Xie· 2 shared Raymond J. DeshaiesiD· 2 shared Aniruddha SahasrabuddheiD· 1 shared Brett LomenickiD· 1 shared Danielle PruittiD· 1 shared Edward L. LaGoryiD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCell Biology

David J. ShermanORCID

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3 papers

Recent·Most cited

Cell BiologyCell ReportsPeer-reviewedOct 1, 2025

PNPLA3-I148M is a Neomorph that Interferes with Two Primary Hepatic Triglyceride Clearance Pathways

David J. Sherman, Lei Liu, Edward L. LaGory…·Raymond J. Deshaies

This paper identifies PNPLA3-I148M as a neomorphic variant that impairs ApoB secretion and lipid metabolism, contributing to fatty liver disease.

9 citationstop 3%

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BiochemistrybioRxivPreprintJun 16, 2025

Novel mechanistic insights for catalytic bioluminescence of mammalian Gaussia Luciferase through mutant and ancestral analysis

Raina M. Borum, Michael B. Lanzillotti, Aniruddha Sahasrabuddhe…·John Ferbas

This study investigates the catalytic mechanism of Gaussia Luciferase through mutant and ancestral analysis, revealing methionine oxidation's role in luminescence and evolutionary changes in substrate turnover.

1 citation

proteomicsexperimental assay

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Cell BiologyProceedings of the National Academy of SciencesPeer-reviewedApr 24, 2024

The fatty liver disease-causing protein PNPLA3-I148M alters lipid droplet-Golgi dynamics

David J. Sherman, Lei Liu, Jennifer L. Mamrosh…·Raymond J. Deshaies

This study investigates the cellular effects of the PNPLA3-I148M variant, revealing its role in altering lipid droplet-Golgi dynamics and inducing proteomic and transcriptomic changes associated with liver disease.

39 citationstop 2%

humanproteomics

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