Angelina Lesnikova

This study shows that combining PIKfyve and TMPRSS2 inhibitors intranasally protects mice from SARS-CoV-2 lung infection and reduces cell death.

This study shows that SARS-CoV-2 can infect a small fraction of human cortical neurons via the endosomal pathway, and this infection can be blocked by apilimod.

This paper shows that nitric oxide nitrates TRKB receptors, impairing BDNF signaling and reducing neuronal plasticity through endocytosis and degradation.

This study shows that reduced PTPσ expression improves short-term memory but impairs long-term memory retention in mice, suggesting PTPσ's role in memory retention through TRKB signaling.

This study shows that chondroitinase and antidepressants promote plasticity in the adult visual cortex by enhancing TRKB signaling in parvalbumin neurons through inhibition of PTPσ.

This study shows that FTY720 treatment after symptom onset in an AD mouse model improves synaptic and memory deficits through anti-inflammatory effects.