Todd Sulchek

This paper introduces CurvSeq and CurvSee to analyze prostate cancer morphology and molecular profiles, identifying cancer-associated genes and morphomechanical niches linked to progression.

This study examines how dexamethasone-induced ocular hypertension affects segmental outflow and trabecular meshwork stiffness in mice, finding no significant stiffness differences but increased fibronectin in low-flow regions.

This study uses CRISPR knockout and mechanical sorting to identify genes affecting cell stiffness in ovarian cancer, finding three genes linked to increased stiffness and patient survival.

The paper shows that exogenous sphingomyelinase increases MSC-derived EV yield and alters their cargo, enhancing therapeutic effects in a murine wound model.

This study shows TRPV4 modulates substrate stiffness sensing and transcellular pore formation in Schlemm's canal cells, with implications for glaucoma treatment.

The paper enhances CLAN incidence in GTM3L cells through sorting and substrate stiffness manipulation and models their biomechanical impact on cell stiffness and nuclear resistance.

The paper describes an AFM force mapping pipeline to analyze mechanical properties of cryosectioned soft tissues, showing that repeated measurements, outlier exclusion, and log-normal transformation improve reliability.