C. Ross Ethier

The paper compares transcriptomic differences between high and low flow regions in mouse and human trabecular meshwork to understand intraocular pressure regulation.

This study examines how dexamethasone-induced ocular hypertension affects segmental outflow and trabecular meshwork stiffness in mice, finding no significant stiffness differences but increased fibronectin in low-flow regions.

This study shows that microtubule stability affects Schlemm's canal cell mechanics and outflow facility in glaucoma by altering contractility, stiffness, and pore formation.

This study shows that endothelial cell stiffness and type influence biomechanically-induced transcellular pore formation in Schlemms canal cells.

The paper measures all-trans retinoic acid (atRA) concentrations in mice and develops a model to understand its transport and role in myopia development.

This study shows TRPV4 modulates substrate stiffness sensing and transcellular pore formation in Schlemm's canal cells, with implications for glaucoma treatment.

This study investigates how ambient light and dopamine affect all-trans retinoic acid levels in the mouse eye, finding that light exposure reduces atRA and that dopamine influences atRA levels.

The paper enhances CLAN incidence in GTM3L cells through sorting and substrate stiffness manipulation and models their biomechanical impact on cell stiffness and nuclear resistance.

This study measures anterior and posterior chamber volumes in mice, finding the anterior chamber constitutes 47% of total aqueous humor volume, significantly different from humans, and suggests previous inflow rate estimates may be overestimated.

This study evaluates a fluorescent analog of all-trans retinoic acid as a surrogate for studying its transport and distribution in ocular tissues.

A magnetic cell therapy reduced intraocular pressure in a glaucoma mouse model, with hAMSCs showing greater efficacy than iPSC-TM cells.

This study examines how aging affects intraocular pressure regulation in mice, finding that outflow facility remains stable despite age-related tissue changes.

This study investigates the role of pectinate ligaments in maintaining the biomechanical stability of the aqueous outflow pathway in mice across different ages.

The paper describes an AFM force mapping pipeline to analyze mechanical properties of cryosectioned soft tissues, showing that repeated measurements, outlier exclusion, and log-normal transformation improve reliability.