Tao Hong

This study identifies neural correlates of combinatorial reasoning in rhesus macaques by analyzing single-unit activity in the dorsolateral prefrontal cortex during decision-making tasks.

The paper identifies cell type-specific enhancers for the DLPFC in NHPs using single nucleus RNA-Seq and ATAC-Seq, validates them with AAV injections, and demonstrates functional expression in specific neuron types.

This study shows that dopamine responses encode probability distributions of reward prediction errors, with rare rewards amplifying these responses and enhancing learning and arousal.