Jesper Mosolff Mathiesen

This study identifies and characterizes nanobodies that act as potent positive allosteric modulators of the calcium-sensing receptor, offering new tools for research and potential therapeutic applications.

This paper identifies a negative allosteric modulator of the μ-opioid receptor that blocks agonist activity and enhances naloxone efficacy, offering potential for safer opioid overdose reversal.

The paper presents structures of GABAB receptor dimers and homomers, revealing the role of ECL2 in ligand binding and G protein activation.

The paper presents the cryo-EM structure of the glucagon receptor bound to a ligand and G-protein, revealing structural insights into ligand efficacy and activation mechanism.