Cancer BiologyNature CancerPeer-reviewed
Selective Mitochondrial Respiratory Complex I Subunit Deficiency Causes Tumor Immunogenicity
Jiaxin Liang, Tevis Vitale, Xixi Zhang…·Pere Puigserver
This study shows that deleting specific mitochondrial Complex I subunits, Ndufs4 and Ndufs6, enhances tumor immunogenicity and sensitivity to immune checkpoint blockade in mouse melanoma models.
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