Author

John David Klement

Augusta UniversityORCID 0000-0003-4334-4076Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:host-pathogen & immune response· 1 Assay:metagenomics· 1 Assay:scRNA-seq· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

Dakota B. PoscheliD· 2 shared Huidong ShiiD· 2 shared Kebin LiuiD· 2 shared Alyssa D. MertingiD· 1 shared Amanda BarrettiD· 1 shared Chunwan LuiD· 1 shared Dafeng YangiD· 1 shared Huabin ZhuiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersImmunology

Dakota B. PoschelORCID

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2 papers

Recent·Most cited

ImmunologybioRxivPreprintFeb 20, 2026

Distinct and cooperative roles of host and tumor Osteopontin in colorectal cancer liver metastasis

Patrick Czabala, Yang Zhao, John David Klement…·Kebin Liu

This study investigates the distinct and cooperative roles of host and tumor-derived Osteopontin in colorectal cancer liver metastasis using genetic knockout models and spatial transcriptomics.

1 citation

mousespatial transcriptomics

𝕏 PostBluesky

ImmunologyCell ReportsPeer-reviewedOct 1, 2024

PD-L1 Restrains the PD-1hiNrp1loTGFb+ Treg to block IL6+ Neutrophil tumor infiltration to Suppress Inflammation-driven Colorectal Cancer

Dakota B. Poschel, John David Klement, Alyssa D. Merting…·Kebin Liu

This study shows PD-L1 suppresses inflammation-driven colorectal cancer by regulating Tregs, neutrophils, and gut microbiota through the PD-L1/L. murinus/PD-1hiNrp1loTGFβ+ Treg/IL6+ neutrophils pathway.

14 citations

mousemetagenomics

𝕏 PostBluesky