Aneel K. Aggarwal

This paper describes the structure and function of M.BceJIV, a DNA methyltransferase in Burkholderia cenocepacia, showing it binds two DNA sequences simultaneously for methylation.

This study characterizes the multivalent interactions of XRCC4 and XLF CTRs, showing they form condensates that enhance DNA ligation in vitro and suggest roles in NHEJ dynamics and cancer biology.

This study resolves crystal and cryo-EM structures of the SPARTA system to elucidate its activation mechanism involving nucleic acid binding and oligomerization.

The paper shows that phosphorylated CTCF binds the SIRT1 promoter under oxidative stress, activating a cardioprotective transcriptional program in cardiomyocytes.