Hong Lü

This study investigates the role of liver-specific glucocorticoid receptor (GR) in alcoholic liver disease using knockout and knockin mice, finding that GR deficiency worsens steatosis and liver injury while GR overexpression provides protection.

This study uses multi-omic analysis to identify a neuroprotective astrocyte state in Huntington disease that correlates with delayed disease onset and neuroprotection.

This study investigates how HNF4 and GR regulate lipid metabolism in mice on a high-fat-high-sugar diet, showing their cooperative role in preventing fatty liver and hyperlipidemia.