Taylor Russo

The paper identifies cell-type-specific SASP ligand-receptor pairs that mediate paracrine senescence spreading in human brain cells and shows that targeting these factors can prevent senescence spread.

This study shows that nuclear import defects drive cell cycle dysregulation in neurodegeneration by impairing nuclear import pathways and causing cell cycle re-entry in neurons.

The paper identifies cell type-specific senescence-associated transcriptional regulators in midbrain cell lines using PCA and regulatory network inference.

This study identifies a gene regulatory pathway involving SATB1, MIR22HG, and GBA that leads to glucocerebroside accumulation and cellular senescence in dopaminergic neurons, contributing to Parkinson's Disease and aging.