Author

Soma Sengupta

Tufts UniversityORCID 0000-0003-4577-1397Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Alessandra FloriiD· 1 shared Andrew M. BaschnageliD· 1 shared Aniruddha Sunil KarveiD· 1 shared Chenran WangiD· 1 shared Dan IonascuiD· 1 shared Daniel Pomeranz KrummeliD· 1 shared Debanjan BhattacharyaiD· 1 shared Donatien Kamdem ToukamiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperCancer Biology

Alessandra FloriORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintAug 27, 2026

GABAergic Circuit Activation Induces a Therapeutically Responsive State for anti-PD-L1 Immunotherapy in Glioblastoma

M Scalera, Elisa De Santis, Filippo Rossi…·Mario Costa

This study shows that activating GABAergic circuits with baclofen enhances the effectiveness of anti-PD-L1 immunotherapy in glioblastoma, leading to tumor regression and prolonged survival in mice.

DOI 10.64898/2026.08.26.747200

mousebulk RNA-seq

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Cancer BiologyCancersPeer-reviewedSep 15, 2024

GABA(A) receptor activation drives GABARAP-Nix mediated autophagy to radiation-sensitize primary and brain-metastatic lung adenocarcinoma tumors

Debanjan Bhattacharya, Riccardo Barrile, Donatien Kamdem Toukam…·Soma Sengupta

This paper shows that activating GABA(A) receptors in lung cancer cells triggers autophagy via GABARAP-Nix interaction, enhancing radiation sensitivity and reducing toxicity in preclinical models.

15 citations

mouseexperimental assay

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