Author
University of SheffieldORCID 0000-0003-4615-2379Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
Recent·Most cited
Jodie R. Malcolm, Olympia Physouni, Lola K Kelly…·Peter J O’Toole
A 3D-printed OpenFlexure Microscope adapted for humid incubators, with relocated electronics, ASA printing and 22 Ω current-limiting resistors, records 48-hour label-free docetaxel responses that CellPhe can analyse.
Sylvia Whittle, Tobias A Firth, Max C. Gamill…·Alice L. B. Pyne
The paper introduces an enhanced TopoStats tool using deep learning to automate and quantify AFM data, enabling detailed structural analysis of biomolecules.
Laura Wiggins, Jodie R. Malcolm, Karen Hogg…·William J. Brackenbury
This study uses live-cell imaging and automated phenotyping to characterize cancer-stromal interactions, revealing phenotypic changes in breast cancer cells exposed to cancer-associated fibroblasts.
Elizabeth P. Holmes, Max C. Gamill, James Iain Provan…·Alice L. B. Pyne
This paper introduces a high-throughput AFM-based pipeline using deep learning to trace DNA topology, revealing new insights into DNA structures and their interactions.
Laura Wiggins, Peter J. O'Toole, William J. Brackenbury, Julie C. Wilson
The paper quantifies variability in manual and automated cell segmentation and tracking methods, showing their impact on phenotypic metrics and reproducibility.