Author

Mark Jordan Althoff

University of Colorado AnschutzORCID 0000-0003-4628-8444Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Research Focus:cancer & tumor microenvironment· 3 Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Austin E. GilleniD· 3 shared Brett M. StevensiD· 3 shared Craig T. JordaniD· 3 shared Regan MilleriD· 3 shared Sweta B. PateliD· 3 shared Ana VujoviciD· 2 shared Angelo D’AlessandroiD· 2 shared Anna E. KrugiD· 2 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

Austin E. GillenORCID

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3 papers

Recent·Most cited

Cancer BiologyBlood Cancer DiscoveryPeer-reviewedJul 17, 2026

The Nicotinamide Salvage Pathway is a Metabolic Vulnerability of High-Risk MDS Stem Cells

Sweta B. Patel, Daniel R Moskop, Steven Moreira…·Eric Martin Pietras

This study identifies NAMPT as a metabolic vulnerability in HR-MDS HSPCs, showing its inhibition reduces their survival and disease burden.

1 citation

humanbulk RNA-seq

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Cancer BiologybioRxivPreprintMay 22, 2025

Therapy resistance in AML is mediated by cytoplasmic sequestration of the transcriptional repressor IRF2BP2

Mark Jordan Althoff, Mohd Minhajuddin, Brett M. Stevens…·Craig T. Jordan

This study identifies IRF2BP2 cytoplasmic sequestration by MCL1 as a mechanism driving venetoclax and azacitidine resistance in AML through ACSL1 derepression.

DOI 10.1101/2025.05.22.655396

humanbulk RNA-seq

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Cancer BiologyCancer DiscoveryPeer-reviewedMay 23, 2024

Targeting Acute Myeloid Leukemia Stem Cells Through Perturbation of Mitochondrial Calcium

Anagha Inguva Sheth, Krysta L. Engel, Hunter Tolison…·Craig T. Jordan

This study identifies mitochondrial calcium utilization as a metabolic requirement of venetoclax-resistant acute myeloid leukemia stem cells and shows that targeting mitochondrial calcium uptake can eradicate these cells.

61 citationstop 1%

humanbulk RNA-seq

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