Matteo T. Degiacomi

This study uses molecular dynamics simulations and Markov state models to compare activation mechanisms of tyrosine kinases, revealing kinase-specific conformational ensembles.

Carbonara uses SAXS data to predict alternative protein conformations, enabling more accurate MD simulations of solution-state dynamics.

The paper investigates how cardiac stress regulates Filamin C dimerisation through phosphorylation-modulated interactions with HSPB7, revealing evolutionary conservation of this mechanism.

The paper investigates how multivalent interactions between SARS-CoV-2 spike protein, ACE2 receptor, and patient-derived antibodies influence viral entry and antibody inhibition.

The paper shows that dimeric subunits of sHsps are functional units for substrate capture, and that dimer stability affects chaperone efficiency.