Philipp Kukura

This paper introduces a method for continuous mass photometry of single molecules, enabling long-term observation of biomolecular interactions with high mass precision and temporal resolution.

This study investigates how ligand binding dynamically influences QR2 dimerization and function using native mass spectrometry.

This study directly observes and quantifies the self-assembly of virus-like particles using mass photometry and single-molecule trapping, revealing the role of multivalent interactions and first-passage dynamics in achieving specific assembly.

This study identifies species-specific allosteric remodelling in Ebola virus GP that underlies differences in entry mechanisms across Ebolavirus species.

This paper introduces a method using mass photometry with supported lipid bilayers to detect and measure proteins in complex mixtures without prior purification.

This paper introduces modular DNA nanosensors that enable label-free, multiplexed single-molecule mass photometry to resolve protein biochemical states in complex media without washing or immobilisation.

This study presents the cryo-EM structure of DISC1, revealing its homotetrameric architecture and its ability to bind multiple partner proteins.

This paper introduces a deep learning method to classify mass photometry events, improving single-molecule mass measurement accuracy by reducing artifacts and enhancing resolving power.

This paper provides guidelines for optimizing mass photometry to achieve high mass resolution and detection limits while maintaining simplicity.

This study identifies NIPBL and STAG1's roles in cohesin-mediated DNA loop extrusion by analyzing their differential DNA-cohesin interactions and ATP-dependent regulation.

This study identifies how CSB enhances SNM1A nuclease activity during ICL repair by interacting with its nuclease core and altering substrate conformation.

The paper investigates how multivalent interactions between SARS-CoV-2 spike protein, ACE2 receptor, and patient-derived antibodies influence viral entry and antibody inhibition.

This study shows that short RAD52 oligomers, not rings, mediate single-strand DNA annealing and homology detection, challenging the prevailing ring-based model.

This study elucidates how McsB, a bacterial kinase, regulates protein degradation by switching between open and closed oligomer forms in response to stress.

This study uses interferometric scattering microscopy to track membrane protein motion in live neurons, revealing compartmentalized plasma membrane structures.