Tian Zhao

This study evaluates lycopene's antitumor effects in lung cancer models, showing dose-dependent tumor regression and safety, with mechanisms involving PI3K/AKT pathway inhibition and apoptosis induction.

The paper develops a co-culture model of lung cancer organoids and peripheral blood mononuclear cells to study systemic anti-tumor immunity and predict immunotherapy outcomes.

The paper uses single-cell RNA sequencing on lung cancer organoids to study the tumor immune microenvironment and identifies key genes and T cell activity factors related to immunotherapy response.