Jonathan L. Coloff

The paper develops an analytical pipeline to identify and target endocrine therapy-insensitive cells in ER+ breast cancer using single-cell RNA sequencing and functional validation in organoid models.

This study shows that extracellular glutathione supports tumor growth by providing amino acids through catabolism, and inhibiting this process slows tumor growth.

This study shows that ET-resistant breast cancer cells are more sensitive to ceramide-induced endoplasmic reticulum stress, mediated through TRAM1, leading to cell death.

The paper shows that arginine restriction in the tumor microenvironment limits lipid synthesis in pancreatic cancers, making them susceptible to polyunsaturated fatty acids via ferroptosis.

This study identifies ASCT2 as the primary serine transporter in cancer cells and shows its role in purine biosynthesis and therapeutic targeting.