Tomasz P. Rygiel

The paper quantifies the discrepancy between population-average and single-cell suppression of pY-STAT1/3 by JAK inhibitors, showing that strong average suppression leaves many cells with elevated responses.

This study identifies liver sinusoidal endothelial cells as the primary cells responsible for hemoglobin clearance, revealing their role in heme detoxification and iron homeostasis through macropinocytosis and the BMP6-hepcidin axis.