Jack Brelstaff

imAgeScore predicts cellular age using Cell Painting features, identifies age-modulating compounds, and validates rejuvenation effects in human fibroblasts.

This study shows that Aβ aggregates trigger TLR4 less efficiently than LPS due to slower Myddosome formation and longer lifetimes of larger Myddosomes.

The paper shows that microglia phagocytosing neurons with tau aggregates become hypofunctional and release tau seeds, contributing to tauopathy progression.