Sojin An

This paper designs a CD81-binding mini-protein using deep learning to block HCV entry, showing high affinity, stability, and antiviral activity.

This study investigates how Legionella pneumophila's SET domain enzymes methylate histone H3K14, revealing structural mechanisms for substrate specificity and nucleosome engagement.

This paper introduces a graphene-based affinity cryo-EM grid (GFD-A) for capturing endogenous protein complexes, achieving resolutions of 2.71 Å for tagged proteins and 3.0–3.9 Å for endogenous RNase MRP and RNase P.

The paper identifies neuron-specific microexon splicing in chromatin regulators, showing that PHF21A loses DNA-binding function in neurons while retaining H3K4me0 recognition, contributing to brain development.

This study identifies how MMADHC uses Co-S coordination lability to transfer cobalamin to methionine synthase, explaining homocystinuria caused by MMADHC variants.

The paper shows Epe1 regulates epigenetic inheritance through non-enzymatic interactions with Swi6HP1 and Clr3, independent of its catalytic activity.