ImmunologybioRxivPreprint
CD8 T-cell dysfunction is linked with CAR T-cell failure and can be mitigated by a non-alpha IL-2 agonist, pegenzileukin
Patrick Kevin Reville, Irtiza N. Sheikh, Ahyun Choi…·Michael Green
The paper identifies dysfunctional CD8 CAR T-cells in rrLBCL tumors and shows that pegenzileukin mitigates this dysfunction, improving CAR T-cell responses.