Roberto A. Avelar

ECMExplainer decodes cellular stress states and aging trajectories by analyzing matrisome gene-pair ratios across fibroblast transcriptomes.

The paper identifies senescent cell heterogeneity by analyzing stress response enrichment in bulk RNA-seq data and proposes a model based on Stress Response Modules.

The paper updates six databases in the Human Ageing Genomic Resources (HAGR) focusing on genes, drugs, and genetic variants related to ageing and longevity.

This study identifies a loss of cell identity in ageing and cancer using transcriptomic data, showing distinct patterns in gene expression associated with patient survival.

The paper identifies genes and enhancers associated with lifespan and body mass in great apes through evolutionary and molecular analysis.

The paper introduces scAgeCom, an atlas of age-related intercellular communication changes in 23 mouse tissues, using the scDiffCom package to analyze single-cell RNA-seq data from two consortia.

The paper curates a database of senescence-associated genes and performs systems biology analyses to identify novel regulators and pathways of cellular senescence.