Long Xiao

This study identifies and quantifies developmental canals in C. elegans embryogenesis that suppress noise and stabilize development, revealing how cell-level stochasticity affects phenotypic outcomes.

The paper shows that V-ATPase asymmetrically segregates the NuRD complex during cell division, influencing daughter cell survival or apoptosis through pH differences.

The paper constructs a single-cell protein atlas of 266 transcription factors in C. elegans embryos, revealing combinatorial regulatory codes and lineage-specific functions in spatiotemporal patterning.

This study quantifies gene expression plasticity across four metazoan species, identifies conserved regulatory elements, and links plasticity to gene function and disease.

This paper introduces a gradient two-photon microscopy technique that enables rapid volumetric imaging with reduced phototoxicity by using two axially gradient excitation beams.

The paper quantifies and shows that cellular position noise during C. elegans embryogenesis is deterministic and regulated by lineage and developmental factors.