Christopher R. Bethel

This study investigates how {Omega}-loop mutations in PDC-3 β-lactamase affect its active site dynamics and catalytic activity through molecular simulations.

This study identifies emerging resistance in KPC variants of K. pneumoniae to CZA, FDC, and FPZ, with mutations in specific regions linked to collateral resistance.

This paper investigates how enmetazobactam and tazobactam inhibit GES-1, an ESBL, revealing structural and mechanistic differences in their acyl-enzyme complexes.

This study shows that sulopenem combined with cefuroxime or durlobactam synergistically inhibits Mycobacterium abscessus, with BLIs enhancing antibacterial effects.