Author

Jessica G. H. Bruystens

University of California San DiegoORCID 0009-0000-8192-814XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 3 Assay:proteomics· 3 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

Susan Serota TayloriD· 3 shared Gerald Tan· 2 shared Jian WuiD· 2 shared Alexis LonaiD· 1 shared Annabel LeeiD· 1 shared Benjamin R. MyersiD· 1 shared Carlos G. GonzaleziD· 1 shared Corvin D. ArvesethiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersBiochemistry

Susan Serota TaylorORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

BiochemistrybioRxivPreprintJun 29, 2026

Selective knockout of PKA regulatory subunits reveal opposite catalytic and metabolic consequences with implications for Alzheimer's disease

Leigh-Ana M. Rossitto, Tsan Wen Lu, Yuliang Ma…·Susan Serota Taylor

This study shows that knocking out PKA regulatory subunits RI and RII leads to distinct metabolic and phosphorylation changes, with RI KO increasing Tau phosphorylation linked to Alzheimer's disease.

DOI 10.64898/2026.06.26.734839

humanproteomics

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BiochemistryNature Structural & Molecular BiologyPeer-reviewedApr 30, 2026

A Structural Mechanism for Noncanonical GPCRSignal Transduction in the Hedgehog Pathway

William Paul Steiner, Nathan Iverson, G Liu…·Benjamin R. Myers

The paper reveals how phosphorylation of SMO in the Hedgehog pathway stabilizes a conformation that inhibits PKA-C, providing a structural mechanism for noncanonical GPCR signaling.

9 citationstop 1%

proteomicsexperimental assay

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Cell BiologyMolecular CellPeer-reviewedMar 26, 2024

Molecular Determinants and Signaling Effects of PKA RIα Phase Separation

Julia C. Hardy, Emily H. Pool, Jessica G. H. Bruystens…·Jin Zhang

This study identifies molecular determinants of PKA RIα phase separation and shows how it regulates cAMP compartmentation and PKA-C spatial restriction.

37 citationstop 4%

proteomicsexperimental assay

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