BiochemistryNature Structural & Molecular BiologyPeer-reviewed
A Structural Mechanism for Noncanonical GPCRSignal Transduction in the Hedgehog Pathway
William Paul Steiner, Nathan Iverson, G Liu…·Benjamin R. Myers
The paper reveals how phosphorylation of SMO in the Hedgehog pathway stabilizes a conformation that inhibits PKA-C, providing a structural mechanism for noncanonical GPCR signaling.
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