Author

Sydney M. Brender

Henry Ford HealthORCID 0009-0001-2446-9351Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Organism:human· 1

Frequent Co-Authors

Daniel James Salas-EscabillasiD· 2 shared Erick T. DavisiD· 2 shared Howard C. CrawfordiD· 2 shared Nina G. SteeleiD· 2 shared Simone BenitziD· 2 shared Alec SteepiD· 1 shared Allison M. Wombwell· 1 shared Brian K. TheiseniD· 1 shared

Activity by Year

2024-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersCancer Biology

Daniel James Salas-EscabillasORCID

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2 papers

Recent·Most cited

Cancer BiologyDevelopmental CellPeer-reviewedDec 24, 2024

Tuft cells transdifferentiate to neural-like progenitor cells in the progression of pancreatic cancer

Daniel James Salas-Escabillas, Megan T. Hoffman, Sydney M. Brender…·Howard C. Crawford

The paper shows that metaplastic tuft cells in pancreatic cancer transdifferentiate into neural-like progenitor cells, driven by Myc activity, and this transition is linked to poor patient survival.

21 citations

mouseexperimental assay

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Cancer BiologyCancer DiscoveryPeer-reviewedJul 5, 2024

ROR2 regulates cellular plasticity in pancreatic neoplasia and adenocarcinoma

Simone Benitz, Alec Steep, Malak M. Nasser…·Howard C. Crawford

This study identifies ROR2 as a regulator of cellular plasticity in pancreatic neoplasia, showing it promotes an aggressive PDAC phenotype and resistance to KRAS inhibitors.

29 citationstop 3%

mousehuman

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