Sora Yang

This study shows WEE1 inhibitors trigger the integrated stress response via GCN2 activation, leading to translational shutdown, which can be mitigated by low-dose or combination treatments.

This study uses single-ribosome imaging and simulations to show that transient ribosome collisions promote efficient translation by suppressing ribosome pausing and recycling.

This study develops socRNA imaging to track single ribosomes, revealing ribosomal heterogeneity and translation elongation fidelity.

This study shows co-transcriptional translation in E. coli increases mRNA noise by amplifying transcriptional variability and altering bursting kinetics.

This paper demonstrates the use of zero-mode waveguide nanowells to enable single-molecule detection in live cells by reducing observation volume and background fluorescence.