Ines Delclaux

The paper identifies a lymphatic circuit that sustains stem-like CD8+ T cells by recycling tumor-experienced effector T cells, enhancing immune surveillance and ICB response.

This study identifies HOXD13 as a driver of a developmental program in melanoma that promotes angiogenesis and suppresses T-cell infiltration through a gene regulatory axis involving VEGFA, SEMA3A, and CD73.

This study shows that IFNγ suppresses lymphatic vessel growth and metastasis by altering metabolism and immune function in melanoma.

This study identifies immune niches in NF1 mutant melanoma that promote immune evasion and shows EGFR inhibition can restore immune responses.

This study shows that tRNA modification mcm5s2U34 is essential for stress granule formation and melanoma metastasis, suggesting it as a therapeutic target.

This study shows that FTSJ1-mediated tRNASec methylation enhances oxidative stress resistance and metastatic colonization in melanoma.

The paper tracks anti-viral CD8+ T cells to show lymphatic transit seeds LN TRM, which provide protection against rechallenge.