Yongjia Duan

This study identifies a stepwise pathway for ULK1 recruitment to membranes during autophagy, involving WIPI proteins and a PVP motif in ULK1.

This paper determines the cryo-EM structure of the PI3KC3-C2 complex with Rubicon's PIKBD domain, revealing how Rubicon selectively inhibits PI3KC3-C2 to regulate endolysosome maturation and mitophagy.

This study shows that BCG effector PE18 induces mitochondrial DNA compaction to suppress trained immunity and protective immunity against Mtb.

This study identifies CDC5L as a transcriptional repressor that prevents spontaneous stress granule formation by suppressing PERK-eIF2 signaling.

This study identifies CHMP2B as a regulator of TDP-43 phosphorylation and proteotoxicity through CK1 turnover, independent of autophagy-lysosomal pathways in neurodegenerative diseases.

The paper shows stress induces TDP-43 nuclear bodies via NEAT1-promoted phase separation, which protects cells from toxicity and is disrupted by an ALS mutation.

This study shows PARylation regulates RNP granule dynamics and neurotoxicity of disease-related RNA-binding proteins, with PARP inhibition reducing neurotoxicity in ALS models.