Johanna J. Rajotte

The paper shows that removing tumor-draining lymph nodes does not impair immune checkpoint blockade response, as distant lymph nodes compensate for the loss.

This study identifies NaV1.3 as a druggable target in adult lymphatic muscle that can restore contractility in aging and radiation injury.

This study shows that breast tumors impair antigen presentation in local lymph nodes, which can be overcome by delivering IL1β or adjuvants to distant lymph nodes, improving anti-cancer immune responses.

This study creates a single-cell transcriptomic atlas of lymphatic muscle cells in mice across ages, revealing age-related transcriptional changes and a pro-inflammatory environment in aged cells.