Radoslav Aleksandrov

This study shows that PARG inhibition leads to PARP1 condensation during DNA replication, highlighting Okazaki fragment maturation as a target for enhancing PARGi cytotoxicity.

This study uses live-cell microscopy to analyze PCNA and RPA1 dynamics during replication fork stalling and restart in response to hydroxyurea, revealing distinct processes and the role of ATR in fork restart.

The paper measures ATM and MDC1 recruitment kinetics at DNA lesions and proposes activated ATM diffusion as the mechanism for MDC1 spread beyond the damage site.

CellTool is an open-source software for image analysis and mathematical modeling, offering tools for processing time-lapse microscopy data and custom model fitting.