Tamina Weiss

This study shows Wnt/β-catenin signaling can establish new regulatory elements by remodeling chromatin, beyond its traditional role as a molecular switch.

The paper shows GATA transcription factors modulate Wnt/β-catenin signaling to control cell identity in the intestinal epithelium by repressing secretory lineage genes in stem cells.

The paper maps transcription factor binding across mouse tissues at different developmental stages, revealing tissue-specific activity and conserved regulatory regions with functional relevance in humans.

This study identifies TBX3 as a functional component of the Wnt/β-catenin complex in human colorectal cancer, showing it modulates metastasis-related transcription through direct protein interactions.