BiochemistryJournal of the American Chemical SocietyPeer-reviewed
Covalent 14-3-3 Molecular Glues and Heterobifunctional Molecules Against Nuclear Transcription Factors and Regulators
Qian Shao, Tuong Nghi Duong, Inji Park…·Daniel K. Nomura
This study identifies a covalent ligand, EN171, that enhances 14-3-3 interactions with transcription factors like ER, YAP, and TAZ, inhibiting their activity and demonstrating its use in heterobifunctional molecules to sequester nuclear substrates.
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