Thomas J. Mason

The paper presents the first X-ray structure of an NtA-mediated asymmetric BRAF dimer bound to MEK1, showing it is a catalytically active state, not an intermediate in BRAF activation.

The paper describes the photoactivation mechanism of the B12 photoreceptor CarH using structural and spectroscopic methods, revealing unique intermediates that drive tetramer dissociation.

This study captures time-resolved structures of β2AR modulated by a photoswitchable beta-blocker, revealing conformational changes linked to ligand isomerization and receptor function.

The paper validates a fixed-target delivery system for XFEL crystallography, showing reduced sample consumption and light contamination control for light-sensitive proteins.